GUID is an acronym global unique identifier. It’s a unique ID number that is automatically assigned to any document that a user creates in Microsoft. In other words, every time a new document is created – no matter if it’s a Word file, Excel one or something different entirely. If the document is created on a LAN or Local Area Network, the number also includes the Ethernet address of the workstation on which the document was created. Other files do not have that section of the GUID.